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In a randomized control trial, valproate alone was found to show poorer outcomes for infants than valproate plus levetiracetam in terms of reduction of seizures, freedom from seizures, daily living ability, quality of life, and cognitive abilities

Acta Biochim Pol 70(1):109115 Merrill SJ, Pandiyan B (2018) Untangling thyroid autoimmunity through modeling and simulation

A multi-center phase-II clinical trial, started a few years ago to investigate the biological and clinical effects of rapamycin in people with ALS, is currently underway and will provide important information for further potential trials [312], thus opening new therapeutic perspectives for ALS

However, there are several limitations to the study